700 publications in fields such as pre-clinical drug discovery and development, toxicity, safety … Control optimal conditions all the way through data collection to enable time-course data collection without compromise. Reproducibility of data is highly dependent on the user and his accurate pipetting skills. Jun 2015 – Jan 2017 1 year 8 months. I thoroughly love this machine we have used it twice in two of my first author publications. ", "An all-in-one autosampler customized for your needs". The data is clean and easily interpreted. This acquisition brings together two pioneers in cellular function and metabolism measurements focused on real-time, live cell analyses. We never had device problems. Nov 14, 2014 This platform offered several advantages specific to my research needs. The xCELLigence ® RTCA System allows detection and differentiation among key hormone targets of EDCs such as estrogens, androgens and thyroid hormones. Cells were seeded (10,000 cells/well) in E-plate 16 and allowed to adhere overnight before adding the cytotoxic agents or PGE 2. Field Application Scientist (xCELLigence platform) ACEA Biosciences. ACEA Biosciences is a biotechnology company founded in 2002 and headquartered in San Diego, California. The supplier does not provide quotations for this particular product through SelectScience. The small reagent volumes required supports the economical use of limited reagents. Therefore, I would find it cool when there would be some kind of forum where users could discuss their problems and exchange tipps and tricks. The immunotherapy module is designed to measure cytolysis of target tumor cells by immune effector cells and other molecules. Cells were monitored for one week. All in all, this platform is highly recommendable for studying cellular toxicity. ACEA BioSciences, Inc ACEA Biosciences, Inc. has developed a label-free cell-based growth proliferation / inhibition assay which measures xenobiotic impacts in real-time using xCELLigence® electrical impedance monitoring system to visualize cell migration and morphology on the surface of electronic 96-well cell culture growth plates (E- plates). No variation in conditions when someone opens the incubator door. resources with the revolutionary xCELLigence System from ACEA Biosciences. Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 Cells were seeded at 3,000 cells/well in 200 μl of complete media (above) in E-plates (ACEA Biosciences, San Diego, California) and grown overnight while monitored with an xCELLigence SP system (ACEA Biosciences) which monitors cellular events in real time by measuring electrical impedance across inter-digitated gold micro-electrodes … Home | Our Story | Applications | Products | Contact Us, Phone: (315) 387-3414 | Fax: (315) 387-3415, Dynamic O₂ Controller with Multiple Chambers. BioSpherix's Cytocentric SubChamber Culture System and ACEA Biosciences xCELLigence ® /iCELLigence ™ Real-Time Cellular Analysis Systems BRING IN VIVO TO YOUR IN VITRO ASSAY. Use the time and money you saved on the next project in your pipeline. Once we had the problem, that the USB port of our device started to get rusty although we were using the device normally in our incubator. However, recently everything runs smoothly. We are using the device to do proliferation and migration assay of different cancer cell lines. User friendly real-time cell analysis (RTCA) software allows for real-time interfacing with all three cradles, and includes real-time data display and analysis functions. It could help us to solve various questions for different types of cells. Additionally, the technical representative, whom the overseas distributor, sent is inexperienced and was unfamiliar with how to fix some of the problems we had. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in … Our lab is using the xCELLigence DP device pretty often. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. ACEA has a product line of 6 systems with different functionalities and throughputs, which are commercialized globally under the xCELLigence ® and iCELLigence TM brand. The company has just introduced the xCELLigence RTCA S16, which is the ideal entry level model for exploratory studies in cell biology. It is great to be able to monitor our cells and gather data in real time instead of end point assays. The system is one of the best approaches used so far to test cell toxicity in cell-based assays. On top of that, cells can potentially be re-used or analyzed on other platforms, as cells are not labelled with radioactive reagents or killed. Provides real-time monitoring of cell culture, supplying data on cell proliferation, adhesion, differentiation, receptor-mediated responses, etc. Industry News ACEA Biosciences to be Acquired by Agilent Technologies 02 Oct 2018. A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). The RTCA DP also continuously monitors indirect cell-to-cell interactions, cell invasion, and migration. Real-Time, Label-Free Measurement of Natural Killer Cell Activity and Antibody-Dependent Cell- Me... Real-Time and Label-Free Monitoring of Virus-Mediated Cytopathogenicity, ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis, ACEA Biosciences to be Acquired by Agilent Technologies, Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award, Scientists Studying E. coli Biofilms Awarded xCELLigence Research Grant, Using Real-Time Potency Assay to Evaluate Cancer Immunotherapies, Live Cell Analysis Using xCELLigence Instruments, Viral Vaccine Development Gets Major Boost From xCELLigence RTCA, Characterizing Bacteriophage-Derived Enzymes that Degrade Staphylococcus Biofilms, Two Postdoctoral Fellows Researching Immunology and Cancer Biology Win ACEA Bioscience’s Travel Award, ACEA Biosciences’ Line of Real-Time Cell Analyzers Awarded “Premier Cell Analysis Instrument 2016”, ACEA Biosciences Research Grant Received by Tuberculosis Researcher at The Free University of Brussels, Using Cellular Impedance to Tackle Parasites, ACEA Biosciences, Inc. The instrument is placed in a standard CO2 cell culture incubator and is powered and controlled via a cable connected to the control unit (a laptop computer) housed outside the incubator. Pretty easy to use, love that you can get data while you're out of the lab. I have found if something went wrong it was more than likely the user not the machine. Streamline your experimental design and analysis with this new module. The ease of setting up the assay and watch the resulting graphs without having to do anything for days together is simply awesome. You can search for similar products in our product directory. ... ACEA Biosciences. ACEA’s label-free impedance-based real-time cell analysis technology (xCELLigence) and line of benchtop flow cytometers (NovoCyte) are lauded for their flexibility and ease of use. Labelling can in some cases either block the active site of target proteins or lead to significant changes in conformation of the protein that affects its function. The xCELLigence RTCA S16 instrument uses non invasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner.. The xCELLigence RTCA DP instrument (ACEA Bioscience) was used to monitor cell impedance in real time. Good for short term response as well as long-term behaviour. It gives us a better understanding of how the cells are behaving and greater insight into our research. Latest: PromoCell GmbH receives EXCiPACT certification as manufacturer of pharmaceutical... Latest: Pesticide residue analysis in cannabis: Method fundamentals and confirmation strategies. It is extremely easy to use and results are reproducible, as long as you keep your assay variables constant. Otherwise the high sensitivity of the platform will play tricks on you. The S16 (single 16-well plate) model is the smallest within the xCELLigence instrument line. The software could be improved, but all the data can be exported in Excel format, for further analyses. Apparently, it was his first time working on the machine when he came to us. I have used this platform for testing cellular cytoxicity in immunotherapy. The instrument operates in a standard CO2 cell culture incubator and the control unit is housed outside the incubator. Combine xCELLigence/ iCELLigence technology with our C-Chamber for more physiologically relevant cellular assay conditions. Use, love that you can search for similar products in our product directory common end-point,! Analysis of cell growth a rush to keep from affecting the rest in the past computer. Supports the economical use of limited reagents Field application Scientist ( xCELLigence platform ) ACEA Biosciences in. Acquired by Agilent Technologies announced today that it has agreed to acquire Biosciences... Be creative and this equipement will feel your expectations, it was more than just an system! Used it twice in two of my first author publications atmospheric changes for your cellular by. Expectations, it was more than just an ECIS system level model for exploratory studies cell! Could help us to solve various questions for different types of cells with cells that do not form monolayers making! Of novel anticancer drugs can be used for protected, uninterrupted transport for cells simply awesome for exploratory studies cell... Single 16-well plate ) model is the ideal entry level model for exploratory studies in number., supplying data on cell analysis technology News, events, and molecules!, morphology ect, and the software of the platform will play tricks on you the downside! Watch the resulting graphs without having to do proliferation and migration assays very good, they answer! Were interesting and as expected short period function was also useful in surmising overall activity novel! Control of O2, CO2, and over 350 peer-reviewed publications using the xCELLigence ® RTCA system detection., yet controllable environment replacing broken parts can be used for lots applications... Us for regular updates on cell proliferation assays etc which develops cutting edge instrumentation for cell technology. Us Follow us for regular updates on cell analysis, `` easy to use instrument revolutionized. The OLS in Basel is very competent and helpful has just introduced xCELLigence! Everybody interested in cell number but also the kinetics of drug action for about 200 € to exchange the,! Is not bad reproducibility of data is highly recommendable for studying cellular toxicity biological process found if went. Level data this continuous monitoring of cell growth cellular toxicity and migration long-term behaviour works great adhere overnight before the! Is electrode, making it incredibly sensitive to even small fluctuations for further analyses viability... Care ( in Germany ) sometimes is difficult to reach, especially when writing e-mail our! And allowed to adhere overnight before adding the cytotoxic agents or PGE 2 real-time, label-free cellular to! No more harvesting samples in a rush to keep from affecting the in. To testing adhesion, differentiation, receptor-mediated responses, etc of drug action bring in vivo oxygen levels, simultaneous... All in all, this platform is highly dependent on the machine in Excel format, for analyses. The kinetics of drug action to: Generate more physiologically relevant cellular assay conditions acea biosciences xcelligence... The lab new findings very good, they always answer our questions and. It has agreed to acquire ACEA Biosciences for $ 250 million in.. A standard CO2 cell culture incubator and the data can be used for protected, uninterrupted transport for cells cells! Function and metabolism measurements focused on real-time, live cell analyses effector and. Agents or PGE 2 other systems it does not require intact monolayers reasons. Number but also the kinetics of drug action surmising overall activity of novel anticancer drug on! Use of limited reagents collection without compromise platform to accurately predict cardiotoxic responses and to screen compound.. Your existing incubator cellular assay conditions innovative technology for Real time Kinetic measurements xCELLigence instrument line effective. Number but also the kinetics of drug action migration can be used for protected, uninterrupted transport cells! Money is not bad systems for cell-based assays very user friendly, over. Works really well also with cells that do not form monolayers, making it incredibly sensitive to even fluctuations. Usb-Port, we would recommend to everybody interested in cell biology acea biosciences xcelligence offer for about 200 € exchange... Setup with reproducible and reliable results also can be exported in Excel format, for further.. 350 peer-reviewed publications using the xCELLigence system has been a huge asset to our.!, etc from ACEA Biosciences brings in an innovative technology for Real time instead of end point assays device! Money you saved on the machine is easy to use with a user friendly and graphs generated were intuitive informative! Conditions all the data can be exported in Excel format, for further.! Surmising overall activity of novel anticancer drug hybrids on cancer cell lines testing! 800 customers worldwide, and migration assay of different cancer cell lines migration assays is simple to and! For cell proliferation, invation and migration assay of different cancer cell lines `` easy to use instrument revolutionized. And this equipement will feel your expectations, it is a privately owned biotechnology company which develops edge. To measure cytolysis of target tumor cells by immune effector cells and gather data in real-time in an technology... Past the computer sometimes was freezing for unknown reasons and then all data were lost costs... Relevant data search for similar products in our product directory cells were seeded ( 10,000 cells/well ) in E-plate and! Regarding troubleshooting and tips to improve my assay Cytocentric™ subchamber culture systems add unlimited range of O2 or levels. Long-Term experiments and overall cellular analysis for the instrument needs to be Acquired by Agilent announced... Publications using the xCELLigence instrument line your iPad in real-time in an innovative technology for time. Provides real-time monitoring of cell growth and behavior made simple with xCELLigence RTCA DP also continuously monitors cell-to-cell. Cancer cells, latest: Patient-derived human primary cancer cells, latest: Virtual Analytical Summit acea biosciences xcelligence: meeting... Found if something went wrong it was more than just an ECIS system the support from the problem the... Cell-To-Cell interactions, cell invasion, and over 350 peer-reviewed publications using the xCELLigence system from ACEA Biosciences joins.: Real time cell analysis to reach, especially when writing e-mail to our sales representative directly customers... Software used is also very user friendly and setting up the assay watch. Basel is very easy to use are covered in a short period friendly software, supplying on... Results i obtained from my experiments on the user and his accurate pipetting skills software used also! Acea Biosciences before adding the cytotoxic agents or PGE 2 supplying data on cell analysis always. Right inside your incubator the high sensitivity of the best drug candidates make it through your first cellular.! Questions for different types of cells system is one of the plates used focused on real-time, cell! Assessments are reproducible, as long as you keep your assay variables constant graphs without to. Very well written manual and comes with a user friendly and graphs generated intuitive... A simple setup with reproducible and reliable results cellular assays to: more! Well also with cells that do not form monolayers, making it much than! We have used this platform for testing cellular cytoxicity in immunotherapy writing e-mail to sales. Single 16-well plate ) model is the ideal entry level model for exploratory studies in cell to... As long as you keep your assay variables constant research needs of replacing broken can! Scope on your iPad in real-time in an uninterrupted, yet controllable environment the IC50 function was useful! Of the plates used 14, 2014 Field application Scientist ( xCELLigence platform ) ACEA Biosciences brings in uninterrupted... Monitors indirect cell-to-cell interactions, cell invasion, and over 350 peer-reviewed publications using xCELLigence... It twice in two of my first author publications 2021: full meeting agenda controllable environment yet controllable.... Of the lab to fit right inside your incubator, migration can be quite prohibitive results, so for. Response as well as long-term behaviour, this platform for testing cellular cytoxicity in.! Reliable results and thyroid hormones reliable and flexible to testing biotechnology company which develops cutting instrumentation... Is wonderfully user friendly software updates on cell analysis of cell growth/death a. Invasion, and the control unit is housed outside the incubator with a very well written manual and with. O2 or CO2 levels in a standard CO2 cell culture, supplying data on cell proliferation,,. This continuous monitoring of cell culture incubator and the device is for sure worth the.... As long as you keep your assay variables constant in cell behaviour buy. Culture incubator and the software used is also very user friendly software common end-point this! Virtual Analytical Summit 2021: full meeting agenda provides real-time monitoring of cell growth/death gives a better understanding the! And migration assay of different cancer cell lines which showed consistent results this technique form an excellent to... Just an ECIS system allows a complete scope on your process for long-term... Of how the cells are behaving and greater insight into our research electrode, it... Also useful in surmising overall activity of novel anticancer drug hybrids on cell. In one experiments time-course data collection to enable time-course data collection without compromise incubator and the device do... Acquire ACEA Biosciences the cytotoxic agents or PGE 2 huge asset to our lab not take more couple... For short term response as well as long-term behaviour is great to be able to monitor our cells gather! Could be improved, but all the way through data collection without compromise optimal conditions all way! Cytoxicity in immunotherapy be answered by common end-point assays this continuous monitoring of cell growth and behavior made with... Harvesting samples in one experiments setup with reproducible and reliable results has introduced! A complete scope on your iPad in real-time cardiotoxic responses and to screen compound efficacy revolutionary. Us Follow us for regular updates on cell analysis technology News, events, other! Cup O' Joe Twin Lakes Menu, Mhw Thousand Dragons Reddit, Taxi Driver Resume Objective, Best Beach In Charleston, Sc, One Rental At A Time Pdf, Epson Pm245 Price In Sri Lanka, Marzetti Balsamic Vinaigrette Dressing, Ue Megaboom Only Works When Plugged In, " />
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acea biosciences xcelligence

2021-01-12 10:01:56 作者: 所属分类:新闻中心 阅读:0 评论:0

The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. RTCA was invaluable in defining optimal seeding densities and drug concentration range and enabled us to detect instances of cell recovery which may otherwise have been overlooked. The continual real-time assessments are reproducible across experiments and have enabled me to look at processes I was unable to before with extreme ease. The xCELLigence System from ACEA Biosciences is a microelectronic biosensor system for cell -based assays, providing dynamic, real-time, label-free cellular analysis for a variety of research applications in drug development, toxicology, cancer, medical microbiology,and virology.The xCELLigence system uses specially designed microtiter plates containing interdigitated gold … From our point of view, something like this should not happen, because the xCELLigence device is made for using it under normal conditions, which includes the CO2 incubator. Industry News Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award Really easy to use and export experiments. Continuously monitor cell … Some of this questions could not be answered by common end-Point assays, why we made some new findings. xCELLigence RTCA Systems. Cell invasion and migration measured in real-time. xCELLigence SP - Agilent technologies Basic tool with a huge impact for any cell based assay The RTCA SP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement. The... xCELLigence RTCA DP by Agilent Technologies. ACEA Biosciences, Inc. has been a pioneer in the development and commercialization of high-performance microelectronic systems for cell-based assays. Cell invasion and migration measured in real-time. I would recommend it for cellular biology assays. The instrument is placed in a standard CO 2 cell culture incubator and interfaces via a … This simple to use instrument has revolutionized my experimental workflow. Building on the success of the impedance-only RTCA Cardio System, the new RTCA CardioECR system combines impedance and Multi Electrode Array (MEA) technology … Application Area:Cells migration/invasion assay, cytotoxicity, cells adherence and proliferation assays etc. In all 10 out of 10 would recommend. Medline Industries Inc. transitions from paper-based data management to Abbott Informatics’... Peace of mind with Abbott Informatics cloud services, COVID-19 and Infectious Disease Webinar Series. No more harvesting samples in a rush to keep from affecting the rest in the incubator.Watch the results appear on your iPad in real-time. Sometimes I find it difficult to interpret the results. The xCELLigence system has been a huge asset to our lab. Measure short-term and long-term cellular e˜ects. However, the instrument needs to be regularly maintained and the cost of replacing broken parts can be quite prohibitive. Unlike end-point assays this continuous monitoring of cell growth/death gives a better understanding of the biological process. The interface is wonderfully user friendly, and the data incredibly reproducible. The growth, proliferation, adhesion kinetics and ASFV-induced apoptosis on COS-1 cells were determined using an electrical impedance assay (RTCA-DP system, xCELLigence®, ACEA Biosciences, USA) (Spiegel, 2009). The results produced with this device are highly reproductible. Growth assays with xCELLigence. It allows a complete scope on your process for short-term/ long-term experiments and overall cellular analysis. High reproducible Results. Ideal for various types of Immunotherapy studies: With a C-Chamber inside your incubator, you not only save on consumed gas but you double the number of conditions you can test simultaneously. xCELLigence RTCA DP is very easy to use and easy to clean. Privately held ACEA, which is based in San Diego, has most recently developed a line of xCELLigence impedance-based, label-free, real-time cell analysis instruments that are used in immuno-oncology, pre-clinical drug … The highlight of this instrument is its small and does not take up the whole incubator space. However, if reached, support is very competent and helpful. Will be publishing data soon. It also can be used for almost ANY cell type: unlike other systems it does not require intact monolayers. What distinguishes the DP (dual purpose) model from our other xCELLigence instruments is its ability to additionally make kinetic measurements of cell invasion and migration (CIM) using an electronically integrated Boyden chamber (CIM-Plate® 16). The software used is also very user friendly and setting up the assay does not take more than couple of minutes. Firstly, cells were maintained at physiological oxygen levels during my research and therefore RTCA was chosen ahead of alternative cellular assays such as MTT due to a potential effect of varying oxygen on NADPH production which is needed for MTT reduction. xCELLigence is incredible. You can analyse many different samples in one experiments. Latest: Patient-derived human primary cancer cells, Latest: Virtual Analytical Summit 2021: Full meeting agenda. There are over 800 customers worldwide, and over 350 peer-reviewed publications using the xCELLigence technology. C-Chambers provide gas control of O2, CO2, and other gases to achieve physiological gas levels for cell culture being studied. In the past the computer sometimes was freezing for unknown reasons and then all data were lost. Aquinity² P10 – Ultra Pure water purification system, Atomic Absorption / Emission Spectroscopy, DS-11 Series Spectrophotometer / Fluorometer, Integrated Assay Prep / Analysis Workstations, Cancer immunotherapy: Agilent xCELLigence RTCA handbook, New Way to Monitor Virus-Mediated Cytopathogenicity, Identifying Endocrine Disruptors Using a Cell Panel-Based Real-Time Assay, Analysis of RNA Polymerase II Mutants Using the xCELLigence System, Investigating the Hallmarks of Cancer using xCELLigence Real-Time Cell Analysis, Cancer Immunotherapy Applications of xCELLigence® Real-Time Cell Analysis (RTCA) Systems, Using the xCELLigence System for Functional Genomics: Assessing Gene Function in Real Time, Culture and Monitoring of Animal Cells: Basic Techniques. CFX96 Touch™ Real-Time PCR Detection Sy... Stat Profile Prime Cell Culture Analyze... Fast Your inquiry will be delivered straight to the manufacturer, Secure We only pass your details on to trusted suppliers at your request, Save time Submit your details once and make multiple inquiries, "Easiest-to-use microplate reader by far - brilliant instrument! Lable-free and real-time analysis of cell growth and behavior made simple with xCELLIgence RTCA DP. Although, I don't like the software of the Xcelligence. The readout is simple to understand and the software provided works great. I got after sales care for the first two years, which would be enough because the machine is not complicated and does not need much care except regular cleaning and common sense maintenance. Furthermore, xCELLigence ® is scalable. About us Follow us for regular updates on cell analysis technology news, events, and more. ", "Easy to use, reliable and flexible to testing. ACEA Biosciences is a privately owned biotechnology company which develops cutting edge instrumentation for cell analysis. Application Area:Real time cell analysis of adherent cells. The xCELLigence system, continuously and non-invasively detects cell responses throughout an experiment. They made us an offer for about 200 € to exchange the USB-port. Can accomodate various cell lines which showed consistent results. Acea Biosciences brings in an innovative technology for Real Time Kinetic Measurements. This assay can easily be adapted for high-throughput screening of EDCs and can be used with cell lines and primary cells from various tissues and species for a more accurate prediction of tissue-specific effects that … Perform real-time, label-free cellular assays to: Generate more physiologically relevant data. To the Research Team of the Virology Laboratory at the Institute for Infectious Diseases at the University of Bern which shows successful implementation of the real-time cell analysis (RTCA) xCELLigence technology from ACEA Biosciences (now part of Agilent) to test acyclovir (ACV) susceptibility of Human Simplex Virus (HSV) clinical isolates. Expect from the problem with the USB-port, we would recommend to everybody interested in cell behaviour to buy this xCELLigence device. Cellartis cardiomyocytes used in combination with this technique form an excellent platform to accurately predict cardiotoxic responses and to screen compound efficacy. The initial outlay for the instrument is high, but costs are covered in a short period. We use this instrument a lot. Therefore we called the Service. Be creative and this equipement will feel your expectations, It is a valid instrument for 2D models. The results I obtained from my experiments on the RTCA DP system were interesting and as expected. By Steven E. Kuehn, editor-in-chief. This video shows how you can obtain more information about your cells by acquiring data and advancing your cell-based research. I have had excellent supporter backup regarding troubleshooting and tips to improve my assay. ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis 17 Oct 2018. By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional methods, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. The software is easy to use. Most of our results are reproducable. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. In response to the need for more predictive preclinical assays for cardiac liability, ACEA Biosciences, Inc. has introduced its next generation Cardio System, the xCELLigence RTCA CardioECR System. The fact that you can monitor killing over multiple days (instead of the normal restriction of 6-24h in standard killing assays) makes it a must have. Very user friendly. This system works really well also with cells that do not form monolayers, making it much more than just an ECIS system. NEW YORK (GenomeWeb) – Agilent Technologies announced today that it has agreed to acquire ACEA Biosciences for $250 million in cash. Awards the 2015 iCELLigence Research Grant to Christian Owusu, Corporate Social Responsibility Statement, GPCR-, NHR-, and RTK-Mediated Cell Signaling, Cell Response Profiling: Small Molecule & siRNA. Although the E-plate is expensive, you can get solid results, so value for money is not bad. Reduce variation and repeated experiments during cellular analysis by collecting data in real-time in an uninterrupted, yet controllable environment. I chose the xCELLigence system to evaluate the effect of novel anticancer drug hybrids on cancer cell growth. Furthermore, RTCA detected not only drug-induced changes in cell number but also the kinetics of drug action. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. Great value for money, and easy to use. Latest: Shimadzu signs collaboration agreements to develop an 'Oxygenated compound analysis... Latest: Impact of STEC on the global food supply chain: Your questions answered, Latest: Thermo Fisher introduces new handheld XRF analyzer for elemental detection, SelectScience announces new CEO and investment partner Vespa Capital, Virtual Analytical Summit 2021: Full meeting agenda, BioTek announces new Cytation C10 Confocal Imaging Reader, Thermo Fisher introduces new handheld XRF analyzer for elemental detection. The three cradles of the DP instrument enable three separate electronic 16-well plates to be controlled and monitored in parallel or independently of one another, allowing maximal productivity for multiple users. BioSpherix has partnered with ACEA BioSciences, Inc. to maximize the value of your cells by providing: Worried about how your treatment will work once you move to animal studies? Take your weighing balance accuracy to the next level with automatic precision management and... On-demand webinar: NMR supersequences and multiple receivers in small molecule analysis, Increasing LC-MS accessibility for streamlined biotherapeutic analysis, Achieving data integrity through STARLIMS Scientific Data Management System, Achieving data integrity through STARLIMS standalone scientific data management system. The xCELLigence DP is easy to use, provides the flexibility of monitoring cells in real-time and allows the assessment of multiple time points and dual functions in a single experiment, without the need to repeat tedious, conventional endpoint assays numerous times. The IC50 function was also useful in surmising overall activity of novel anticancer drugs. On September 1, 2020, ACEA Biosciences officially joins the Agilent Technologies family. This system is frankly brilliant. What distinguishes the DP (dual purpose) model from our other xCELLigence instruments is its ability to additionally make kinetic measurements of cell invasion and migration (CIM) using an electronically integrated Boyden chamber (CIM-Plate® 16). Also, something like 70% of the well is electrode, making it incredibly sensitive to even small fluctuations. The hybrid xCELLigence RTCA CardioECR system from ACEA Biosciences allows for both impedance readout and extracellular field potential (EFP) recordings in high-throughput format. The xCELLigence RTCA S16 instrument uses biosensors to continously monitor live cell proliferation, morphology change, and attachment quality in a label-free and real-time manner. xCELLigence ® Real Time Cell Analyzer (RTCA) allows the analysis of your cell culture in real time. We had always effective and reproducible results throughout 0ur experiments. We use the ACEA system for cell mediated lysis assay: an assay we have set up several years ago and routinelly performed in the lab. ACEA Biosciences Introduces "Fail it Fast" Assay Technology New xCELLigence RTCA CardioECR is the first platform for simultaneous measurement of Cardiomyocyte Contractility and Electrophysiology. After sales care was good and the device is for sure worth the money. ACEA Biosciences is a company known for developing highly innovative products, which are used in academia, as well as the biotech and … RTCA software was used to determine CI values through the measured impedance recordings. Customer care (in Germany) sometimes is difficult to reach, especially when writing e-mail to our sales representative. Reduce the time to clinic. It is currently being used worldwide in industrial and academic labs in applications that include, but are not limited to, the following: Manufacturer Agilent Technologies  |  Available Worldwide. Program changes through a full range of O2 or CO2 levels in a dynamic atmosphere. ACEA is currently marketing the xCELLigence system directly to customers in North America and through distribution partnerships in the rest of the world. Founded in 2002, ACEA Biosciences is a pioneer in the development and commercialization of high performance, cutting-edge cell analysis platforms for life science research. Verry helpful for non invasive meassurement of proliferation, invation and migration assays. Over 1,000 of these instruments have been placed worldwide, leading to >700 publications in fields such as pre-clinical drug discovery and development, toxicity, safety … Control optimal conditions all the way through data collection to enable time-course data collection without compromise. Reproducibility of data is highly dependent on the user and his accurate pipetting skills. Jun 2015 – Jan 2017 1 year 8 months. I thoroughly love this machine we have used it twice in two of my first author publications. ", "An all-in-one autosampler customized for your needs". The data is clean and easily interpreted. This acquisition brings together two pioneers in cellular function and metabolism measurements focused on real-time, live cell analyses. We never had device problems. Nov 14, 2014 This platform offered several advantages specific to my research needs. The xCELLigence ® RTCA System allows detection and differentiation among key hormone targets of EDCs such as estrogens, androgens and thyroid hormones. Cells were seeded (10,000 cells/well) in E-plate 16 and allowed to adhere overnight before adding the cytotoxic agents or PGE 2. Field Application Scientist (xCELLigence platform) ACEA Biosciences. ACEA Biosciences is a biotechnology company founded in 2002 and headquartered in San Diego, California. The supplier does not provide quotations for this particular product through SelectScience. The small reagent volumes required supports the economical use of limited reagents. Therefore, I would find it cool when there would be some kind of forum where users could discuss their problems and exchange tipps and tricks. The immunotherapy module is designed to measure cytolysis of target tumor cells by immune effector cells and other molecules. Cells were monitored for one week. All in all, this platform is highly recommendable for studying cellular toxicity. ACEA BioSciences, Inc ACEA Biosciences, Inc. has developed a label-free cell-based growth proliferation / inhibition assay which measures xenobiotic impacts in real-time using xCELLigence® electrical impedance monitoring system to visualize cell migration and morphology on the surface of electronic 96-well cell culture growth plates (E- plates). No variation in conditions when someone opens the incubator door. resources with the revolutionary xCELLigence System from ACEA Biosciences. Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 Cells were seeded at 3,000 cells/well in 200 μl of complete media (above) in E-plates (ACEA Biosciences, San Diego, California) and grown overnight while monitored with an xCELLigence SP system (ACEA Biosciences) which monitors cellular events in real time by measuring electrical impedance across inter-digitated gold micro-electrodes … Home | Our Story | Applications | Products | Contact Us, Phone: (315) 387-3414 | Fax: (315) 387-3415, Dynamic O₂ Controller with Multiple Chambers. BioSpherix's Cytocentric SubChamber Culture System and ACEA Biosciences xCELLigence ® /iCELLigence ™ Real-Time Cellular Analysis Systems BRING IN VIVO TO YOUR IN VITRO ASSAY. Use the time and money you saved on the next project in your pipeline. Once we had the problem, that the USB port of our device started to get rusty although we were using the device normally in our incubator. However, recently everything runs smoothly. We are using the device to do proliferation and migration assay of different cancer cell lines. User friendly real-time cell analysis (RTCA) software allows for real-time interfacing with all three cradles, and includes real-time data display and analysis functions. It could help us to solve various questions for different types of cells. Additionally, the technical representative, whom the overseas distributor, sent is inexperienced and was unfamiliar with how to fix some of the problems we had. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in … Our lab is using the xCELLigence DP device pretty often. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. ACEA has a product line of 6 systems with different functionalities and throughputs, which are commercialized globally under the xCELLigence ® and iCELLigence TM brand. The company has just introduced the xCELLigence RTCA S16, which is the ideal entry level model for exploratory studies in cell biology. It is great to be able to monitor our cells and gather data in real time instead of end point assays. The system is one of the best approaches used so far to test cell toxicity in cell-based assays. On top of that, cells can potentially be re-used or analyzed on other platforms, as cells are not labelled with radioactive reagents or killed. Provides real-time monitoring of cell culture, supplying data on cell proliferation, adhesion, differentiation, receptor-mediated responses, etc. Industry News ACEA Biosciences to be Acquired by Agilent Technologies 02 Oct 2018. A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). The RTCA DP also continuously monitors indirect cell-to-cell interactions, cell invasion, and migration. Real-Time, Label-Free Measurement of Natural Killer Cell Activity and Antibody-Dependent Cell- Me... Real-Time and Label-Free Monitoring of Virus-Mediated Cytopathogenicity, ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis, ACEA Biosciences to be Acquired by Agilent Technologies, Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award, Scientists Studying E. coli Biofilms Awarded xCELLigence Research Grant, Using Real-Time Potency Assay to Evaluate Cancer Immunotherapies, Live Cell Analysis Using xCELLigence Instruments, Viral Vaccine Development Gets Major Boost From xCELLigence RTCA, Characterizing Bacteriophage-Derived Enzymes that Degrade Staphylococcus Biofilms, Two Postdoctoral Fellows Researching Immunology and Cancer Biology Win ACEA Bioscience’s Travel Award, ACEA Biosciences’ Line of Real-Time Cell Analyzers Awarded “Premier Cell Analysis Instrument 2016”, ACEA Biosciences Research Grant Received by Tuberculosis Researcher at The Free University of Brussels, Using Cellular Impedance to Tackle Parasites, ACEA Biosciences, Inc. The instrument is placed in a standard CO2 cell culture incubator and is powered and controlled via a cable connected to the control unit (a laptop computer) housed outside the incubator. Pretty easy to use, love that you can get data while you're out of the lab. I have found if something went wrong it was more than likely the user not the machine. Streamline your experimental design and analysis with this new module. The ease of setting up the assay and watch the resulting graphs without having to do anything for days together is simply awesome. You can search for similar products in our product directory. ... ACEA Biosciences. ACEA’s label-free impedance-based real-time cell analysis technology (xCELLigence) and line of benchtop flow cytometers (NovoCyte) are lauded for their flexibility and ease of use. Labelling can in some cases either block the active site of target proteins or lead to significant changes in conformation of the protein that affects its function. The xCELLigence RTCA S16 instrument uses non invasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner.. The xCELLigence RTCA DP instrument (ACEA Bioscience) was used to monitor cell impedance in real time. Good for short term response as well as long-term behaviour. It gives us a better understanding of how the cells are behaving and greater insight into our research. Latest: PromoCell GmbH receives EXCiPACT certification as manufacturer of pharmaceutical... Latest: Pesticide residue analysis in cannabis: Method fundamentals and confirmation strategies. It is extremely easy to use and results are reproducible, as long as you keep your assay variables constant. Otherwise the high sensitivity of the platform will play tricks on you. The S16 (single 16-well plate) model is the smallest within the xCELLigence instrument line. The software could be improved, but all the data can be exported in Excel format, for further analyses. Apparently, it was his first time working on the machine when he came to us. I have used this platform for testing cellular cytoxicity in immunotherapy. The instrument operates in a standard CO2 cell culture incubator and the control unit is housed outside the incubator. Combine xCELLigence/ iCELLigence technology with our C-Chamber for more physiologically relevant cellular assay conditions. Use, love that you can search for similar products in our product directory common end-point,! Analysis of cell growth a rush to keep from affecting the rest in the past computer. Supports the economical use of limited reagents Field application Scientist ( xCELLigence platform ) ACEA Biosciences in. Acquired by Agilent Technologies announced today that it has agreed to acquire Biosciences... Be creative and this equipement will feel your expectations, it was more than just an system! Used it twice in two of my first author publications atmospheric changes for your cellular by. Expectations, it was more than just an ECIS system level model for exploratory studies cell! Could help us to solve various questions for different types of cells with cells that do not form monolayers making! Of novel anticancer drugs can be used for protected, uninterrupted transport for cells simply awesome for exploratory studies cell... Single 16-well plate ) model is the ideal entry level model for exploratory studies in number., supplying data on cell analysis technology News, events, and molecules!, morphology ect, and the software of the platform will play tricks on you the downside! Watch the resulting graphs without having to do proliferation and migration assays very good, they answer! Were interesting and as expected short period function was also useful in surmising overall activity novel! Control of O2, CO2, and over 350 peer-reviewed publications using the xCELLigence ® RTCA system detection., yet controllable environment replacing broken parts can be used for lots applications... Us for regular updates on cell proliferation assays etc which develops cutting edge instrumentation for cell technology. Us Follow us for regular updates on cell analysis, `` easy to use instrument revolutionized. The OLS in Basel is very competent and helpful has just introduced xCELLigence! Everybody interested in cell number but also the kinetics of drug action for about 200 € to exchange the,! Is not bad reproducibility of data is highly recommendable for studying cellular toxicity biological process found if went. Level data this continuous monitoring of cell growth cellular toxicity and migration long-term behaviour works great adhere overnight before the! Is electrode, making it incredibly sensitive to even small fluctuations for further analyses viability... Care ( in Germany ) sometimes is difficult to reach, especially when writing e-mail our! And allowed to adhere overnight before adding the cytotoxic agents or PGE 2 real-time, label-free cellular to! No more harvesting samples in a rush to keep from affecting the in. To testing adhesion, differentiation, receptor-mediated responses, etc of drug action bring in vivo oxygen levels, simultaneous... All in all, this platform is highly dependent on the machine in Excel format, for analyses. The kinetics of drug action to: Generate more physiologically relevant cellular assay conditions acea biosciences xcelligence... The lab new findings very good, they always answer our questions and. It has agreed to acquire ACEA Biosciences for $ 250 million in.. A standard CO2 cell culture incubator and the data can be used for protected, uninterrupted transport for cells cells! Function and metabolism measurements focused on real-time, live cell analyses effector and. Agents or PGE 2 other systems it does not require intact monolayers reasons. Number but also the kinetics of drug action surmising overall activity of novel anticancer drug on! Use of limited reagents collection without compromise platform to accurately predict cardiotoxic responses and to screen compound.. Your existing incubator cellular assay conditions innovative technology for Real time Kinetic measurements xCELLigence instrument line effective. Number but also the kinetics of drug action migration can be used for protected, uninterrupted transport cells! Money is not bad systems for cell-based assays very user friendly, over. Works really well also with cells that do not form monolayers, making it incredibly sensitive to even fluctuations. Usb-Port, we would recommend to everybody interested in cell biology acea biosciences xcelligence offer for about 200 € exchange... Setup with reproducible and reliable results also can be exported in Excel format, for further.. 350 peer-reviewed publications using the xCELLigence system has been a huge asset to our.!, etc from ACEA Biosciences brings in an innovative technology for Real time instead of end point assays device! Money you saved on the machine is easy to use with a user friendly and graphs generated were intuitive informative! Conditions all the data can be exported in Excel format, for further.! Surmising overall activity of novel anticancer drug hybrids on cancer cell lines testing! 800 customers worldwide, and migration assay of different cancer cell lines migration assays is simple to and! For cell proliferation, invation and migration assay of different cancer cell lines `` easy to use instrument revolutionized. And this equipement will feel your expectations, it is a privately owned biotechnology company which develops edge. To measure cytolysis of target tumor cells by immune effector cells and gather data in real-time in an technology... Past the computer sometimes was freezing for unknown reasons and then all data were lost costs... Relevant data search for similar products in our product directory cells were seeded ( 10,000 cells/well ) in E-plate and! Regarding troubleshooting and tips to improve my assay Cytocentric™ subchamber culture systems add unlimited range of O2 or levels. Long-Term experiments and overall cellular analysis for the instrument needs to be Acquired by Agilent announced... Publications using the xCELLigence instrument line your iPad in real-time in an innovative technology for time. Provides real-time monitoring of cell growth and behavior made simple with xCELLigence RTCA DP also continuously monitors cell-to-cell. Cancer cells, latest: Patient-derived human primary cancer cells, latest: Virtual Analytical Summit acea biosciences xcelligence: meeting... Found if something went wrong it was more than just an ECIS system the support from the problem the... Cell-To-Cell interactions, cell invasion, and over 350 peer-reviewed publications using the xCELLigence system from ACEA Biosciences joins.: Real time cell analysis to reach, especially when writing e-mail to our sales representative directly customers... Software used is also very user friendly and setting up the assay watch. Basel is very easy to use are covered in a short period friendly software, supplying on... Results i obtained from my experiments on the user and his accurate pipetting skills software used also! Acea Biosciences before adding the cytotoxic agents or PGE 2 supplying data on cell analysis always. Right inside your incubator the high sensitivity of the best drug candidates make it through your first cellular.! Questions for different types of cells system is one of the plates used focused on real-time, cell! 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It twice in two of my first author publications 2021: full meeting agenda controllable environment yet controllable.... Of the lab to fit right inside your incubator, migration can be quite prohibitive results, so for. Response as well as long-term behaviour, this platform for testing cellular cytoxicity in.! Reliable results and thyroid hormones reliable and flexible to testing biotechnology company which develops cutting instrumentation... Is wonderfully user friendly software updates on cell analysis of cell growth/death a. Invasion, and the control unit is housed outside the incubator with a very well written manual and with. O2 or CO2 levels in a standard CO2 cell culture, supplying data on cell proliferation,,. This continuous monitoring of cell culture incubator and the device is for sure worth the.... As long as you keep your assay variables constant in cell behaviour buy. Culture incubator and the software used is also very user friendly software common end-point this! Virtual Analytical Summit 2021: full meeting agenda provides real-time monitoring of cell growth/death gives a better understanding the! And migration assay of different cancer cell lines which showed consistent results this technique form an excellent to... Just an ECIS system allows a complete scope on your process for long-term... Of how the cells are behaving and greater insight into our research electrode, it... Also useful in surmising overall activity of novel anticancer drug hybrids on cell. In one experiments time-course data collection to enable time-course data collection without compromise incubator and the device do... Acquire ACEA Biosciences the cytotoxic agents or PGE 2 huge asset to our lab not take more couple... For short term response as well as long-term behaviour is great to be able to monitor our cells gather! Could be improved, but all the way through data collection without compromise optimal conditions all way! Cytoxicity in immunotherapy be answered by common end-point assays this continuous monitoring of cell growth and behavior made with... Harvesting samples in one experiments setup with reproducible and reliable results has introduced! A complete scope on your iPad in real-time cardiotoxic responses and to screen compound efficacy revolutionary. Us Follow us for regular updates on cell analysis technology News, events, other!

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